Endocrine Abstracts

Alterations in sodium reabsorption in collecting duct epithelium can have severe implications for the normal function of the nephron and may precipitate the development of secondary hypertension. One of the principal protein kinases involved in sodium transport in the nephron is the serum and glucocorticoid regulated kinase (SGK1) that mediates translocation and insertion of the epithelial sodium channel (ENaC) into the plasma membrane. SGK1 appears to be increased in the kidn...